Stevan R. Hubbard

Stevan R. Hubbard, PhD

Adjunct Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
Protein tyrosine kinases, Insulin receptor, Janus kinases, Tyrosine phosphorylation, Histidine phosphorylation, X-ray crystallography, Biophysics
Summary

My laboratory studied the molecular mechanisms by which the insulin receptor and other receptor tyrosine kinases (RTKs) are activated upon ligand binding, and the structural basis for recruitment of downstream signaling proteins to activated receptors.

Phone

212-263-8938

Academic office

540 First Avenue, Skirball Institute

3, 14

New York, NY 10016

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Positions

Adjunct Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Graduate Education

PhD from Stanford University

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

Srivastava, Shekhar; Panda, Saswati; Li, Zhai; Fuhs, Stephen R; Hunter, Tony; Thiele, Dennis J; Hubbard, Stevan R; Skolnik, Edward Y

eLife. 2016 Aug 19; 5:

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation

Hammaren, Henrik M; Ungureanu, Daniela; Grisouard, Jean; Skoda, Radek C; Hubbard, Stevan R; Silvennoinen, Olli

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Apr 14; 112(15):4642-7

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Silvennoinen, Olli; Hubbard, Stevan R

Blood. 2015 May 28; 125(22):3388-92

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state

Cabail, M Zulema; Li, Shiqing; Lemmon, Eric; Bowen, Mark E; Hubbard, Stevan R; Miller, W Todd

Nature communications. 2015 Mar 11; 6:6406

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

Shan, Yibing; Gnanasambandan, Kavitha; Ungureanu, Daniela; Kim, Eric T; Hammaren, Henrik; Yamashita, Kazuo; Silvennoinen, Olli; Shaw, David E; Hubbard, Stevan R

Nature structural & molecular biology. 2014 Jul; 21(7):579-84

Structural basis for the interaction of the adaptor protein grb14 with activated ras

Qamra, Rohini; Hubbard, Stevan R

PLoS one. 2013 Aug; 8(8):e72473

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector

Wynne, Joseph P; Wu, Jinhua; Su, Wenjuan; Mor, Adam; Patsoukis, Nikolaos; Boussiotis, Vassiliki A; Hubbard, Stevan R; Philips, Mark R

Journal of cell biology. 2012 Oct 15; 199(2):317-30

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Bandaranayake, Rajintha M; Ungureanu, Daniela; Shan, Yibing; Shaw, David E; Silvennoinen, Olli; Hubbard, Stevan R

Nature structural & molecular biology. 2012 Aug; 19(8):754-9

See All Publications (47)